GHR growth hormone receptor [hom*o sapiens (human)] - Gene (2024)

Table of Contents
RefSeqs maintained independently of Annotated Genomes RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10 Reference GRCh38.p14 Primary Assembly Alternate T2T-CHM13v2.0 Suppressed Reference Sequence(s) References

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011688.2RefSeqGene

    Range
    4516..302955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000163.5 → NP_000154.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_000154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as V2) and variants 3 through 9 encode the predominant protein (isoform 1).
    Source sequence(s)
    AC113368, AC116343, X06562, Z11801
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000230882.4, ENST00000230882.9
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001242399.2 → NP_001229328.1 growth hormone receptor isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as V9B) has an alternate 5' exon, which includes an in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC113368, AF230801, X06562
    Consensus CDS
    CCDS75239.1
    UniProtKB/TrEMBL
    A0A087X0H5
    Related
    ENSP00000483403.1, ENST00000620156.4
    Conserved Domains (3) summary
    cd00063
    Location:156 → 257
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:323 → 624
    GHBP; Growth hormone receptor binding
    cl21522
    Location:56 → 134
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_001242400.2 → NP_001229329.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as V9A) has an alternate 5' UTR and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AF230800, AF230801, X06562
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000478291.1, ENST00000615111.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. NM_001242401.4 → NP_001229330.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as V3) has an alternate 5' UTR and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AC116343, X06562, Z11851
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. NM_001242402.2 → NP_001229331.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as V7) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AC114941, X06562, Z11853
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000482373.1, ENST00000618088.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  6. NM_001242403.3 → NP_001229332.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229332.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as V1) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, X06562, Z11802
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000478332.1, ENST00000612382.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  7. NM_001242404.2 → NP_001229333.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229333.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as V4) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, X06562, Z11849
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000479846.1, ENST00000612626.4
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  8. NM_001242405.2 → NP_001229334.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229334.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as V8) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, X06562, Z11848
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Related
    ENSP00000442206.2, ENST00000537449.5
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  9. NM_001242406.2 → NP_001229335.1 growth hormone receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as V5) has an alternate 5' UTR exon and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AC113368, AC114941, X06562, Z11850
    Consensus CDS
    CCDS3940.1
    UniProtKB/Swiss-Prot
    P10912, Q9HCX2
    Conserved Domains (3) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:316 → 617
    GHBP; Growth hormone receptor binding
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  10. NM_001242460.2 → NP_001229389.1 growth hormone receptor isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also known as GHRd3, lacks an in-frame coding exon in the 5' region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC113368, AC114941, AC116343
    Consensus CDS
    CCDS56364.1
    UniProtKB/Swiss-Prot
    P10912
    Related
    ENSP00000350335.3, ENST00000357703.6
    Conserved Domains (3) summary
    cd00063
    Location:127 → 228
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:294 → 595
    GHBP; Growth hormone receptor binding
    cl21522
    Location:27 → 105
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  11. NM_001242462.1 → NP_001229391.1 growth hormone receptor isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as GHR1-277) lacks a coding exon in the 3' region, compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113368, X06562
    Consensus CDS
    CCDS75240.1
    UniProtKB/TrEMBL
    A0A087X162
    Related
    ENSP00000483926.1, ENST00000622294.2
    Conserved Domains (2) summary
    cd00063
    Location:149 → 250
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:49 → 127
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10Reference GRCh38.p14 Primary Assembly

    Range
    42423439..42721878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1Alternate T2T-CHM13v2.0

    Range
    42678916..42974806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001242461.1: Suppressed sequence

    Description
    NM_001242461.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
GHR growth hormone receptor [hom*o sapiens (human)] - Gene (2024)

References

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